Endocrine Abstracts

Introduction: Hashimoto’s thyroiditis (HT) is multifactorial disease, caused by a complex interplay of genetic, hormonal, and environmental influences that provoke the development of inappropriate immune responses against thyroid on multiple levels and the initiation of a long-standing autoimmune reaction. Interaction between cellular and humoral immunity is base of HT’s pathogenesis. Our research focuses on the functional activity and the quantity of T regulatory an...

Objectives: to modify the classification of autoimmune adrenal insufficiency (AAI).Methods: n=8 patients with early stages (potential and latent) of AAI were included (table 1).Results: Based on the analysis of clinical and laboratory data of patients, a modified classification of AAI has been developed (table 2).Table 1. Characteristics of patient...

Background: During pregnancy, the physiology of the thyroid gland undergoes important changes. As a result, change levels of thyroid hormones. In the latest clinical guidelines, experts have recommended to perform population-based studies to determine reference intervals for thyroid hormones.Aim: To evaluate the reference intervals of free thyroxine in different trimesters of pregnancy in women living in regions with mild iodine deficiency.<p class="...

Introduction: In Russia, full-scale studies aimed at assessing the incidence of endocrine autoimmune diseases (eAID) in adult patients with vitiligo have not been conducted.Objectives: analysis of occurrence of eAID in patients with vitiligo.Methods: 1) The first part of the study included 39 patients aged 19-73 years with endocrine pathology and vitiligo, who were initially examined in Endocrinology Research Centre. 2)The second p...

Introduction: Research into autoimmune disorders associated with COVID-19 in the middle of an ongoing COVID-19 pandemic is an important and urgent challenge. We focus on the potential relationship between coronavirus infection and other autoimmune diseases, and the positive therapeutic effect of the treatment of severe forms of COVID-19 with drugs traditionally used in the treatment of rheumatological diseases. The results of this study are a starting point for understanding t...

Pregnant women are at risk of developing diseases associated with deficiency of essential micronutrients.Objective: To assess the prevalence of vitamin D deficiency among pregnant women and its dependence on the trimester of pregnancy.Methods: We examined 476 pregnant women at different gestational periods from three regions of Russia (Moscow, Ivanovo, Smolensk). Concentration of 25(OH)vitamin D (ng/ml) was estimated by immunometri...

Introduction: CYP11B2 is a key enzyme of primary aldosteronism, and several factors are involved in the regulation of CYP11B2 expression and the overproduction of aldosterone. Somatic mutations in aldosterone-driver genes are strongly associated with CYP11B2 expression and have been only detected in the CYP11B2-positive tumor area, indicating that aldosterone producing adenoma (APA) intratumoral heterogeneity corresponds to non-uniform CYP11B2 expression in neoplastic cells. I...

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are commonly associated with coronary artery disease (CAD). Recent studies demonstrated that microRNAs (miRNAs) are involved in the pathogenesis of CAD.Aim: To study miRNA-26a, microRNA-33a and microRNA-33b expression in patients with obesity.Methods: MiRNAs were detected in peripheral blood samples of 66 patients, aged 48–65 years. Patients with BMI 30.0–39.9 kg/m...

Introduction: Lymphoma of the thyroid gland is an uncommon condition occurring primarily in older women. Most patients have a short history of enlarging thyroid or a neck mass causing tracheal compression. There is also a strong association between thyroid lymphoma and Hashimoto’s thyroiditis. The diagnosis is established by biopsy. The conventional approach to treatment is combination of radiation therapy with multi-agent chemotherapy, while there is no significant role ...